Hypertonic saline for treating raised intracranial pressure: literature review with meta-analysis.

Hypertonic saline for treating raised intracranial pressure: literature review with meta-analysis A review

210 J Neurosurg / Volume 116 / January 2012 INTRACRANIAL hypertension following neurological injury is often associated with poor outcomes.13 Increased ICP reduces CBF and can lead to brain herniation and death. The Brain Trauma Foundation has recommended that therapy to reduce ICP should begin at pressures > 20 mm Hg. Hyperosmolar therapy is a commonly used treatment for intracranial hypertens...

High-osmolarity saline in neurocritical care: systematic review and meta-analysis.

BACKGROUND AND PURPOSE Intracranial hypertension and cerebral edema are known contributors to secondary brain injury and to poor neurologic outcomes. Small volume solutions of exceedingly high osmolarity, such as 23.4% saline, have been used for the management of intracranial hypertension crises and as a measure to prevent or reverse acute brain tissue shifts. We conducted a systematic literatu...

Comparison of Equimolar Doses of Mannitol and Hypertonic Saline for the Treatment of Elevated Intracranial Pressure After Traumatic Brain Injury: A Systematic Review and Meta-Analysis: Erratum

Hypertonic saline versus mannitol for the treatment of elevated intracranial pressure: a meta-analysis of randomized clinical trials.

OBJECTIVES Randomized trials have suggested that hypertonic saline solutions may be superior to mannitol for the treatment of elevated intracranial pressure, but their impact on clinical practice has been limited, partly by their small size. We therefore combined their findings in a meta-analysis. DATA SOURCES We searched for relevant studies in MEDLINE, EMBASE, the Cochrane Central Register ...

Salt or sugar for your injured brain? A meta-analysis of randomised controlled trials of mannitol versus hypertonic sodium solutions to manage raised intracranial pressure in traumatic brain injury.

BACKGROUND Rising intracranial pressure (ICP) is a poor prognostic indicator in traumatic brain injury (TBI). Both mannitol and hypertonic sodium solutions are used to treat raised ICP in patients with TBI. OBJECTIVE This meta-analysis compares the use of mannitol versus hypertonic sodium solutions for ICP control in patients with TBI. DATA SOURCES AND STUDY ELIGIBILITY Randomised clinical ...